JIAN SHU

shujian@nwu.edu.cn

DETAILS

Address:School of Medicine, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai Beilu, Xi’an 710069, Shaanxi Province, China.

Email:shujian@nwu.edu.cn

Website :https://orcid.org/0000-0002-2938-4218

Web of Science (clarivate.cn)

RESEARCH INTERESTS

lCancer diagnosis and Salivary diagnostics:Detection of cancer and development of diagnostic tools based on salivary glycopatterns data and machine learning algorithms.

lSalivary glycopatterns for natural regulation of oral microbiota:Investigation of the relationship between salivary glycoproteins and oral microorganisms, and to explore the regulatory mechanism

WORK EXPERIENCE

Lecturer (June 2023 - present)

School of Medicine, Faculty of Life Science & Medicine

Northwest UniversityShaanxi, Xi’an China

Post-doc (July 2020 - June 2023)

College of Life Sciences, Faculty of Life Science & Medicine

Northwest University Shaanxi, Xi’an China

EDUCATIONAL

College of Life Sciences,Northwest University, Xi’an, China

PhD,Biochemistry and molecular biologySep 2017-June 2020

Research title：The relationship between neoglycoproteins and oral microbiota in gastric cancer patients,Supervisors Prof. Zheng Li

College of Life Sciences,Northwest University, Xi’an, China

MSc, Biochemistry and molecular biologySep 2014-June 2017

Research title:The Aberrant Glycosylation of Salivary Protein in Gastric Cancer Patients,Supervisors Prof. Zheng Li

College of Life Sciences,Northwest University, Xi’an, China

BSc, National base forLife Science and TechnologySep 2010-June 2014

FOUNDATION

lNational Natural Science Foundation of China (NSFC), 32101030, (1/2022-12/2024)(In research,Leader)

lScientific Research Program Funded by Shaanxi Provincial Education Department, (Proram No, 23JK0687), (1/2023-12/2024)(In research,Leader)

lNatural Science Basic Research Program of Shaanxi, 2021JQ-446, (1/2021-12/2022)(Concluded,Leader)

lNorthwest University Excellent Doctoral Dissertation Cultivation Project, YYB17018, (10/2017-6/2020)(Concluded,Leader)

lNSFC, 81871955, (1/2019-12/2022) (Concluded, Participant)

lNSFC, 81773180, (1/2018-12/2021) (Concluded, Participant)

lNSFC, 21705127(1/2018-12/2020) (Concluded, Participant)

lNSFC, 81670577(1/2017-12/2020) (Concluded, Participant)

PUBLICATUONS(H-index=10)

lDang J#,Shu J^#,*, Wang R, Yu H, Chen Z, Yan W, Zhao B, Ding L, Wang Y, Hu H^*, Li Z^*. The glycopatterns of Pseudomonas aeruginosa as a potential biomarker for its carbapenem resistance, Microbiology Spectrum, 2023, DOI: https://doi.org/10.1128/spectrum.02001-23 (Co-first/Co-correspondingauthor)

lJ Shu, X Ren, H Cheng, et al. Beneficial or detrimental: Recruiting more types of benign cases for cancer diagnosis based on salivary glycopatterns, International Journal of Biological Macromolecules, 2023, https://doi.org/10.1016/j.ijbiomac.2023.126354. (IF=8.2, Top)

lJ Shu, H Yu, X Ren, et al. Role of salivary glycopatterns for oral microbiota associated with gastric cancer, International Journal of Biological Macromolecules, 2022, 209:1368-1378. (IF=8.2, Top)

lX Ren^#,J Shu^#, J Wang, et al. Machine learning reveals salivary glycopatterns as potential biomarkers for the diagnosis and prognosis of papillary thyroid cancer, International Journal of Biological Macromolecules, 2022, 215:280-289. (IF=8.2, Top, Co-first author)

lJ Shu, J Ma, X Ren, et al. The Abnormal Glycopatterns of Salivary Glycoproteins in Esophageal Squamous Cell Carcinoma Patients, Frontiers in Chemistry, 2021, 9(62):637730. (IF=5.545)

lH Yu^#,J Shu^#, Z Li. Lectin microarrays for glycoproteomics: an overview of their use and potential [J]. Expert Review of Proteomics, 2020; 17(1): 27-39.

lJ Shu, L Dang, D Zhang, et al. Dynamic analysis of proteomic alterations in response to N-linked glycosylation inhibition in a drug-resistant ovarian carcinoma cell line [J]. FEBS Journal. 2019; 286(8):1594-1605. (IF=4.390)

lJ Shu, H Yu, H Du, et al. Identification of N- and O-linked glycans recognized by AAL in saliva of patients with atrophic gastritis and gastric cancer[J]. Cancer biomarkers, 2018; 22(4): 669-681.

lJ Shu, H Yu, X Li, et al. Salivary glycopatterns as potential biomarkers for diagnosis of gastric cancer[J]. Oncotarget. 2017,8(22):16082.

lJ Shu, H Yu, X Liu, et al. New progress of glycoprotein glycans associated with gastric cancer[J]. Progress in Biochemistry & Biophysics, 2016, 43(5):449-460.

lX Liu, H Yu, Y Qiao, J Yang,J Shu, et al. Salivary glycopatterns as potential biomarkers for screening of early-stage breast cancer[J]. EBioMedicine, 2018, 28, 70-79.

lJ Yang, X Liu,J Shu, et al. Abnormal Galactosylated–Glycans recognized by Bandeiraea Simplicifolia Lectin I in saliva of patients with breast Cancer. Glycoconjugate Journal, 2020, 37, 373-394.

lH Zhu, M Liu, H Yu, X Liu, Y Zhong,J Shu, et al. Glycopatterns of urinary protein as new potential diagnosis indicators for diabetic nephropathy. J Diabetes Res, 2017, 2017:5728087.

lJ Zhang, Y Zhong, P Zhang, H Du,J Shu, et al. Identification of abnormal fucosylated-glycans recognized by LTL in saliva of HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Glycobiology, 2019,29(3):242-259.

lQ Jian, Z Yang,J Shu,et al. Lectin BS‐I inhibits cell migration and invasion via AKT/GSK‐3β/β‐catenin pathway in hepatocellular carcinoma, Journal of cellular and molecular medicine, 2018, 22 (1), 315-329

INVENTION

ØZL202110984286.1,(China,Authorization date:2023-06-06)

ØZL202110910586.5,(China,Authorization date:2023-04-07)

ØZL202010062124.8,(China,Authorization date:2023-03-24)

ØZL202010059785.5,(China,Authorization date:2023-02-10)

ØZL202010397235.4,(China,Authorization date:2022-12-23)

ØZL201910074569.5,(China,Authorization date:2021-10-22)

ØZL201811277891.X,(China,Authorization date:2021-06-25)

ØZL201711369378.9,(China,Authorization date:2019-12-03)

ØZL201611073359.7, (China,Authorization date:2018-10-30)

ØZL201610007829.3, (China,Authorization date:2018-05-04)

ØZL 201610123938.1, (China,Authorization date:2017-12-01)

ØZL201610315822.8, (China,Authorization date:2017-12-01)

SOFTWARE

ØRegistration NO.: 2018R11L720814

ØRegistration NO.: 2018R11L081301

ØRegistration NO.: 2018R11L224025

ØRegistration NO.: 2017R11L121971

OTHERS

Editorial Review Board: Technology in Cancer Research & Treatment

Peer Review: Emerging Microbes & Infections

International Journal of Biological Macromolecules