主要研究方向

功能基因组学、表观遗传学、开发新方法

主持及参与科研项目

(1) 国家自然科学基金青年科学基金项目，32100468，基于SELEX方法研究增强子差异甲基化影响前列腺癌风险的分子机制，2022.1-2024.12，30万元，在研，主持

(2) 国家自然科学基金面上项目，32070596，开发新方法研究内源逆转录病毒HERV-H在胚胎发育中调控染色质高级结构的分子机理，2021.1-2024.12，58万元，在研，参与

(3) 国家自然科学基金面上项目，32270634，对CTCF结合位点附近染色质DNA去甲基化分子机制的研究，2023.1-2026.12，54万元，在研，参与

已发表论文

(1)Fan Ligang#, Sun Wei#, Lyu Yitong, Ju Furong, Sun Wenju, Chen Jie, Ma Haiqian, Yang Shifei, Zhou Xiaomin, Wu Nan, Yi Wenkai, Chen Erfei, Villaseñor Rodrigo, Baubec Tuncay, Yan Jian*, Chrom-seq Identifies RNAs at Chromatin Marks,Science Advances, 2024, 10(31): eadn1397.

(2)Fan Ligang#, Wang Tingting#, Hua Canfeng#, Sun Wenju#, Li Xiaoyu, Grunwald Lucas, Liu Jingui, Wu Nan, Shao Xiaolong, Yin Yimeng, Yan Jian*, Deng Xin*, A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae,Nature Communications, 2020, 11(1).

(3)Wang Tingting#, Sun Wenju Sun#,Fan Ligang#, Hua Canfeng#, Wu Nan, Fan Shaorong, Zhang Jilin, Deng Xin*, Yan Jian*, An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence,eLife, 2021, 10: e61885.

(4)Fan Shaorong#, Sun Wenju#,Fan Ligang#, Wu Nan, Sun Wei, Ma Haiqian, Chen Siyuan, Li Zitong, Li Yu, Zhang Jilin, Yan Jian*, The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity.Computational and Structural Biotechnology Journal, 2022, 20: 5040 -5044.

(5)Fan Ligang, Zhao Lei, Hu Wei, Li Weina, Novák Ondřej, Strnad Miroslav, Simon Sibu, Friml Jiří, Shen Jinbo, Jiang Liwen, Qiu Quan-Sheng*, Na+, K+/H+ antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development,Plant Cell and Environment, 2018, 41(4): 850-864.

(6)Fan Ligang#, Wang Guannan#, Hu Wei, Pantha Pramod, Tran Kieu-Nga, Zhang Hua, An Lizhe, Dassanayake Maheshi*, Qiu Quan-Sheng*, Transcriptomic view of survival during early seedling growth of the extremophyte Haloxylon ammodendron,Plant Physiology and Biochemistry, 2018, 132: 475-489.

(7)Tan Daisylyn Senna#, Chen Yanpu#, Gao Ya, Bednarz Anastasia, Wei Yuanjie, Malik Vikas, Ho Derek Hoi-Hang, Weng Mingxi, Ho Sik Yin, Srivastava Yogesh, Velychko Sergiy, Yang Xiaoxiao,Fan Ligang, Kim Johnny, Graumann Johannes, Stormo Gary D, Braun Thomas, Yan Jian, Schöler Hans R, Jauch Ralf*, Directed Evolution of an Enhanced POU Reprogramming Factor for Cell Fate Engineering,Molecular Biology and Evolution, 2021, 38(7): 2854-2868.

(8)Yi Wenkai#, Li Jingyu#, Zhu Xiaoxuan#, Wang Xi#,Fan Ligang, Sun Wenju, Liao Linbu, Zhang Jilin, Li Xiaoyu, Ye Jing, Chen Fulin, Taipale Jussi, Chan Kui Ming*, Zhang  Liang*, Yan Jian*, CRISPR-assisted detection of RNA-protein interactions in living cells,Nature Methods, 2020, 17(7): 685-688.

(9)Lv Shasha#, Wang Lu#, Zhang Xiao, Li Xiaojiao,Fan Ligang, Xu Yanli, Zhao Yingjia, Xie Huichun, Sawchuk Megan G, Scarpella Enrico, Qiu Quan-Sheng*, Arabidopsis NHX5 and NHX6 regulate PIN6-mediated auxin homeostasis and growth,Journal of Plant Physiology, 2020, 255:153305.

(10) Zhu Xiaojie#, Pan Ting#, Zhang Xiao,Fan Ligang, J. Quintero Francisco, Zhao Hong, Su Xiaomeng, Li Xiaojiao, Villalta Irene, Mendoza Imelda, Shen Jinbo, Jiang Liwen, M. Pardo Jose, Qiu Quan-Sheng*, K+ Efflux Antiporters 4, 5, and 6 Mediate pH and K+ Homeostasis in Endomembrane Compartments,Plant Physiology, 2018, 178(4): 1657-1678.

(11) Zheng Sheng, Pang Ting,Fan Ligang, Qiu Quan-Sheng*, A novel AtKEA gene family, homolog of bacterial K+/H+ antiporters, plays potential roles in K+ homeostasis and osmotic adjustment in Arabidopsis,PLoS One, 2013, 8(11).