王 盼

姓名:王盼

职称:工学博士/硕士生导师

部门:生物工程系

电子邮箱:panwanghgxy@nwu.edu.cn

办公地点:太白校区科技楼五楼


主要研究领域

发酵工程、微生物酶学、合成生物学


工作及教育经历

2019.12~至今,西北大学在职博后;

2018.07~至今,西北大学化工学院,讲师;

2012.09~2018.06,华南理工大学,发酵工程,博士(直博);

2008.09~2012.07,华南理工大学,生物工程,本科


指导学生项目及竞赛

12020年陕西省大学生创新创业训练计划项目(S202010697500)—重组糖苷酶在毕赤酵母中的高效表达及催化人参皂苷的条件优化。指导学生:袁博韬,付健铭,李思齐;

22021年“国际基因工程机器大赛(International Genetically Engineered Machine competition,简称iGEM)”。指导学生:李佳程,武阳,常泽文,马宇欣,牛子阳等;获全球银奖;

32021年“生物+”国际青年科技作品展评大会—人参皂苷的转化之旅。指导学生:付健铭,李智杰,李佳程等;获优秀作品奖。


主要科研项目

1、国家自然科学基金青年项目(22108229),β-葡萄糖苷酶高效分泌及催化合成稀有人参皂苷Compound K的机制研究,2022.01-2024.12。在研,主持;

2、陕西省教育厅专项科研计划项目(20JK0938),微生物转化法高效制备稀有人参皂苷CK的研究,2020.01-2021.12。在研,主持;

3、西安市科协青年人才托举计划项目,基于蛋白质组学的黑曲霉耐受人参皂苷Rb1的胁迫响应机制研究,2019.11-2021.11。已结题,主持;

4、西北大学科研启动基金(338050059),高转化及耐受人参皂苷Rb1菌株的筛选及机制研究,2018.11-2020.11。已结题,主持;

5、国家重点研发计划项目-合成生物学(2009YFA0905200),人造蛋白质合成的细胞设计构建及应用,2020.01-2024.12。在研,骨干成员,参加;

6、国家自然科学基金面上项目(21978236),人参皂苷Rk3靶向PD-L1调节肠道菌群对肝癌的抑制及作用机制研究,2020.01-2023.12。在研,参加;

7、国家自然科学基金面上项目(21978235),人参皂苷Rg5通过调节肠道菌群缓解II型糖尿病代谢紊乱的作用机制研究,2020.01-2023.12。在研,参加。


研究成果

1. Xue Bai, Rongzhan Fu, ZhiguangDuan,Pan Wang, Chenhui Zhu, Daidi Fan. Ginsenoside Rk3 alleviates gut microbiotadysbiosis and colonic inflammation in antibiotic-treated mice. Food Research International, 2021, 146(6), 110465.

2.Jing Cao,Pan Wang, Yannan Liu,Chenhui Zhu, Daidi Fan. Double crosslinked HLC-CCS hydrogel tissue engineering scaffold for skin wound healing[J]. International Journal of Biological Macromolecules, 2020, 155:625-635.

3. Gang Liu, Zhiguang Duan,Pan Wang, Daidi Fan, Chenhui Zhu. Purification, characterization, and hypoglycemic properties from Eurotium cristatum spores in Fuzhuan brick tea. RSC Advances, 2020, 10(37):22234-22241.

4. Mimi Xing, Rongzhan Fu, Yannan Liu,Pan Wang, Pei Ma, Chenhui Zhu, Daidi Fan. Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors[J].Food & function, 2020,11(5):4123-4137.

5.Pan Wang,Yin Lin, Chenjuan Zou, Fengguang Zhao, Shuangyan Han. Construction and screening of a glycosylphosphatidylinositol protein deletion library inPichia patoris[J]. BMC Microbiology, 2020, 20(262):1-12.

6.Chengjuan Zou,Pan Wang, Shuli Liang, Ying Lin. Deletion of Gcw13 represses autophagy inPichia pastoriscells grown in methanol medium with sufficient amino acids[J].Biotechnology Letters, 2019,41(12):1423-1431.

7. Chengjuan Zou,Pan Wang, Shuli Liang, Shuangyan Han, Suiping Zheng, Ying Lin. Deletion of the GCW13 gene derepresses Gap1-dependent uptake of amino acids inPichia pastorisgrown on methanol as the sole carbon source[J]. Biochemical and Biophysical Research Communications, 2018, 501(1):226-231.

8.Pan Wang,Li Zhang, Rebecca Fisher, Meiqi Chen, Shuli Liang, Shuangyan Han, Suiping Zheng, Haixin Sui, Ying Lin. Accurate analysis of fusion expression ofPichia pastorisglycosylphosphatidyl- inositol-modified cell wall proteins[J].Journal of Industrial Microbiology & Biotechnology, 2017,44(9):1355-1365.

9.Kun Zhang, Zi Jin,Pan Wang, Suiping Zheng, Shuangyan Han, Ying Lin.Improving the catalytic characteristics of lipase-displaying yeast cell by hydrophobic modification[J]. Bioprocess and Biosystems Engineering, 2017, 40(11):1689-1699.

10. Jie He, Chyongere Hsieh, Yongping Wu, Thomas Schmelzer,Pan Wang, Ying Lin, Michael Marko, Haixin Sui. Cryo-FIB specimen preparation for use in a cartridge-type cryo-TEM[J]. Journal of Structural Biology, 2017,199(2):114-119.

11.Pan Wang, Jie He, Yufei Sun, Matthew Reynolds, Li Zhang, Shuangyan Han, Shuli Liang, Haixin Sui, Ying Lin.Display of fungal hydrophobin on thePichia pastoriscell surface and its influence onCandida antarcticalipase B[J].Applied microbiology and biotechnology, 2016, 100(13):5883-5895.

12.王盼,朱晨辉,赵婧,范代娣.合成生物学在蛋白质功能材料领域的研究进展[J].合成生物学,2021,2(1):46-58.

13. 赵婧, 王盼, 刘彦楠, 傅荣湛, 段志广, 范代娣.人参皂苷的定向生物转化研究进展[J]. 化工进展,2021, 40(3):1238-1247.